Triamcinolone acetonide ta is an extensively used glucocorticoid. Saussurea lappa is costus plant from the family of compositae. Investigation of phytochemical activities of saussurea lappa c. Lipsch belonging to family asteraceae table 1, commonly known.
Medicinal plants are sources of novel drug discovery targets. About 25,000 biological active compounds are reported by different scientists. Pdf comparative study of inula racemosa and saussurea. Saussurea lappa clarke compositae is a traditionally known and potent plant which is well considered for its medicinal uses in different indigenous indian systems of medicine. Background and aim of work liver fibrosis is a major health problem associated with high morbidity and mortality, particularly in egypt. Pdf antiulcerogenic activity of saussurea lappa root. Lappadilactone 1, dehydrocostuslactone 2, and costunolide 5 exhibited the most potent cytotoxicity with cd50 values in the range 1.
It founds in himalyan region and the root is widely used for various diseases due to its broad medicinal property. The herb excludes the worms found in intestines and other body parts. Saussurea lappa, indigenous medicine, costunolide, antiic uses. Download fulltext pdf download fulltext pdf ameliorative effects of saussurea lappa root aqueous extract against ethephoninduced reproductive toxicity in male rats. It was found that both species are really separated from each. Comparative study of inula racemosa and saussurea lappa on. The costus root is about a human fingers size with a woody part that is. It is a perennial plant with robust, erect stem of height 12m 6 which is stout. Saussurea is especially prized in tibetan and traditional chinese medicine and is among the most sacred plants in india, where it is used to pay homage to the goddess nanda devi. Third group was given ethephon at a dose 200 mgkg bw. Inula racemosa and saussurea lappa have been used in ayurvedic system for the management of diabetes.
Saussurea lappa extract on house dust miteinduced atopic dermatitis in ncnga mice hyesun lim1,3, hyekyung ha1, hyeunkyoo shin1, and soojin jeong2,4, saussurea lappa has been reported to possess antiatopic properties. Many of these compounds have been found to possess a wide range of biological activity such as anticancer, antiinflammatory, antihepatotoxic, antiviral, etc. Mu xiang, kuth, costus saussurea lappa decne, aucklandia lappa, aplotaxis lappa decne, saussurea costus. Induction of apoptosis by saussurea lappa and pharbitis. Saussurea lactone is from costus root oil saussurea lappa, probably formed by pyrolysis of dihydrocostunolid. Author links open overlay panel vasundhara thakur a 1 savita bains a 1 shivalika pathania a shailesh sharma b ravneet kaur a kashmir singh a. Hence, this study explored, for the first time, the possible beneficial effects of s. Saussurea costus, commonly known as costus or kuth, is a species of thistle in the genus saussurea native to india. Preliminary phytochemical investigation and evaluation. Mu xiang, kuth, costus saussurea lappa decne, aucklandia lappa, aplotaxis lappa decne, saussurea costus culture.
Evaluation and antiarthritic activity of root of saussurea lappa. Saussurea costus, commonly known as costus or kuth, is a species of thistle in the genus. Sesquiterpenoids from costus root oil saussurea lappa. Pdf around 3000 species of saussurea are known, however saussurea lappa clarke which is perennial herb and has been traditionally used as anticancer. Alantolactone from saussurea lappa exerts antiinflammatory effects by inhibiting chemokine production and stat1 phosphorylation in tnf and ifninduced in. Herbs, usually perennial or sometimes biennial, sometimes subshrubs, cauliferous or stemless, often with woody caudex. Subsequently, a new crystalline lactone saussurea lactone c15h20o2rao and verma, 1951 and costunolide were isolated from costus saussurea lappa root oil rao.
Costus saussurea lappa has been used as traditional chinese medicine. Saussurea lappa sl has been used as a traditional herbal medicine to treat abdominal pain and tenesmus, and has been suggested to possess various biological activities, including antitumor, antiulcer, antiinflammatory, antiviral, and cardiotonic activities. Despite significant progress in phytochemical and biological analyses of s. We performed this study to understand the molecular basis underlying the antitumor effects of saussurea lappa, pharbitis nil, plantago asiatica and taraxacum mongolicum, which have been used for herbal medicinal treatments against cancers in east asia. We analyzed the effects of these medicinal herbs on proliferation and on expression of cell growthapoptosis related molecules, with. Phytochemistry of saussurea lappa after thorough literature survey revealed various varied and copious metabolites such as sesquiterpenes, flavonoids, phytosterols, lignans, terpenes. It is popularly known as kuth root or costus and used in various traditional system of medicine for its antiulcer, anticonvulsant, anticancer, hepatoprotective, antiarthritic, antiviral activities. It is a long erect herb found mostly in northern mountainous regions of pakistan and india gupta et al. Wed like to understand how you use our websites in order to improve them. Based on the literature survey, it was reported that various pharmacological activities. Saussurea costus is the only common medicinal herb listed in appendix i critically endangered of the cites index. Saussurea lappa is a traditionally wellknown plant for its medicinal uses in different indigenous systems of medicine. In india it found abundantly in himalayan region810. The efficacy of herbal auklandia costus saussurea lappa s.
Introduction saussurea lappa is a potential herb belonging to family asteraceae table 1. Pdf ameliorative effects of saussurea lappa root aqueous. Study of hepatoprotective activity of saussurea lappa root extract. Saussurea is a genus of about 300 species of flowering plants in the thistle tribe within the daisy family, native to cool temperate and arctic regions of asia, europe, and north america, with the highest diversity in alpine habitats in the himalaya and central asia. Modulatory effects of saussurea lappa root aqueous extract. Bioassaydirected fractionation of saussurea lappa led to the isolation of a novel lappadilactone 1 and seven sesquiterpene lactones 2. The current study was conducted to examine the possible modifying effects of costus s. In this era, worldwide interest has been directed towards using natural antioxidants to guard against drug side effects.
Plants from the start are being used for the welfare of human and animals. Phytochemical screening and determination of biological. It is widely used in the treatment of asthma, ulcer, stomach problems and inflammatory diseases. View enhanced pdf access article on wiley online library html view download pdf for offline viewing. Saussurea lappa, cb clarke is the root of a perennial herb commonly grew in cold and humid. Essential oils extracted from the root have been used in traditional medicine and in perfumes since ancient times. The one at the bottom shows how the blood vessels become inflamed, irritating the nerve endings around them and causing pain simon, 2003. Takao kataoka, kazuo nagai, in progress in biotechnology, 2002. Download fulltext pdf download fulltext pdf comparative study of inula racemosa and saussurea lappa on the glucose level in albino rats article pdf available july 1995 with 341 reads. These factors drive demand for the plant as well as high market prices. Costunolide and dehydrocostus lactone were purified from the extract of a herbal medicine, mokko saussurea lappa clarke as active principles that block ctlmediated cytotoxicity 14. Costunolides, an important sesquiterpene lactone stl isolated from saussurea lappa, are the major pharmaceutical ingredient of various drug formulations. Costus, or kuth, with the scientific name saussurea costus or saussurea lappa, is a thistle species that is native to south asia, especially in jammu, kashmir, the himalayas, the kishenganga valley, and the western ghats this gorgeous perennial plant is characterized by purple floret heads and long lyrate leaves. Saussurea lappa clarke is the member of family compositae.
People are still using plants and their decoction for different diseases. Antioxidants free fulltext saussurea lappa ethanolic. Pdf chemical composition and pharmacological activities. Pdf 2014 stm publishing research progress on active. This plant is famous due to its high medical importance. We ask that users who download significant portions of the database cite the hmdb paper in any resulting. Both saussurea lappa and saussurea costus are threatened due to the unregulated collection and illegal trade of the medicinal plant. The genomewide expression profile of saussurea lappa. Download fulltext pdf download fulltext pdf chemical composition and pharmacological activities of saussurea lappa. Ameliorative effects of saussurea lappa root aqueous. Common names include sawwort and snow lotus, the latter used for a number of high altitude species in central asia. Saussurea costus synonymous with saussurea lappa, locally known as kuthis a robust perennial herb of the western himalayas, distributed in pakistan and india. The head at the top shows the brain before a migraine. It is mainly regulated by hepatic stellate cells, which acquire a fibrogenic character in response to oxidant.
The effect of sl on breast cancer metastasis, however, is unknown. Qust, saussurea, costus, saussurea lappa, kut, unani medicine, ayush. Pdf study of hepatoprotective activity of saussurea. This study was designed to evaluate protective effect of saussurea lappa root aqueous extract against ethephon 2. The study was designed to investigate the antiulcer activity of ethyl acetate extract of the saussurea lappa root using different models of gastric and duodenal ulceration in rats. Saussurea lappa clarke, a species out of almost 300 species of sassurea, has been used as a traditional medicine almost globally for a variety of ailments. Saussurea costus is effective as a treatment for cough, asthma, bronchitis and cholera. The gale encyclopedia of alternative medicine, edited by laurie j. Their structures were elucidated on the basis of extensive spectroscopic analysis.
As an effective expectorant, it helps to treat asthma by making breathing easier, clearing and relaxing bronchiole. Saussurea lappa is a famous medicinal plant with many biologically active compounds. Conservation status and therapeutic potential of saussurea. The plant under evaluation was saussure a lappa, a plant of asteraceae, one of the bestknown species within this genus, was commonly known as costus in english. Research article open access saussurea lappa extract. Their structures were determined on the basis of spectral data including 1d and 2d nmr and hreims. Gastric ulcers were induced by oral administration of ethanol. Identification of the genes and transcriptional regulation of costunolide biosynthesis pathway in s.
Review of its traditional uses, phytochemistry and pharmacology. Quality control and phytochemical validation of saussurea lappa. Alternatively, you can download the pdf file directly to your computer, from where it can be opened using a pdf reader. Pdf phytochemical evaluation and antiarthritic activity. The species is endemic to a geographically limited part of the himalayas, and grows on moist slopes at altitudes of 26004000 m. Study of hepatoprotective activity of saussurea lappa root.
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